The Wolves midfielder was substituted 14 minutes from the end of last weekends draw against Cardiff City with a blister on his foot and that has become infected making him doubtful for the match against The Pilgrims at Molineux on Saturday afternoon.
Fellow midfielder Nigel Quashie will definately miss the game with a chest infection.
"Matt has a blister which had a reaction and he has got an infection so he is certainly a doubt," manager Mick McCarthy has said.
"Nigel had no chance. He is poorly."