The winger has made only nine Premier League appearances, and none since November 2009, because of a series of injuries, most recently operations on both knees.
But, after two reserve-team run-outs, Kightly has been included in Wolves' squad for the short trip to Aston Villa.
Wolves boss McCarthy told a press conference: "Everyone believed Kights would be a good Premier League player and let's hope he gets the chance over these last nine games.
"It pleases me for him as much as anything. I know the supporters will be thrilled to see him back."
Source: PA
Source: PA