Ebanks-Blake suffered a recurrence of a hamstring injury after appearing as a substitute during the weekend home draw with Fulham, after initially suffering the injury in the previous game against Everton when he came off at half-time.
Stephen Hunt, Steven Mouyokolo and David Jones will be added to the other 17 players on duty against the Cottagers.
Striker Kevin Doyle (medial ligament) misses out but full-back George Elokobi (hamstring) could return for the derby with West Brom on May 8.
Source: PA
Source: PA